Endocrine Abstracts

Background: Patients who require levothyroxine (LT4) supplementation after total thyroidectomy often have difficulty achieving target TSH levels. Several studies have attempted to develop a dosing schedule considering different factors such as age, gender, weight, or body mass index (BMI) as potential determinants of the correct dose of LT4. The objective of this study is to determine if a scheme that uses the percentage of body fat (%BF) measured by CUN-BAE is more accurate t...

Introduction: Sulphonylureas (SU) are an effective therapy for type 2 diabetes (T2DM). As insulin secretagogues, hypoglycemia is a potencial adverse effect. Hypoglycemia may cause neuroglycopenic brain injury, which can mimetize stroke and infections of the central nervous system. Case ReportThe authors report the case of an autonomous 71 year-old woman, with medical history of hypertension and T2DM, treated with enalapril and gliclazide, that was admitted in the Emergency Roo...

Introduction: Adrenocortical carcinoma (ACC) is a rare neoplasm with a variable but overall poor prognosis. The presentation is heterogeneous usually with mass effect and less often with evidence of hormonal secretion. About half of cases the tumors are hormonally active most commonly with cortisol secretion followed by sexual hormones production, being rare the aldosterone secretion.Case report: A 41-year-old male presented with hypertensive crisis and ...

Background: Acromegaly results from excess growth hormone (GH) secretion by a pituitary adenoma in 95% of the cases. Discordant acromegaly is defined by the elevation of GH with normal levels of insulin-like growth factor type 1 (IGF-1) or normal levels of GH associated with an elevation of IGF-1. Its an important situation in the follow-up period of patients with acromegaly because there is little information about patient treatment, comorbidities and follow-up. The objective...

Introduction: Sheehan syndrome (SS) is caused by postpartum necrosis of the pituitary gland, associated with significant haemorrhage during or after delivery. It is rare in developed countries, but still frequent in underdeveloped ones. We present a rare presentation of this syndrome.Clinical case: A 48 years old black woman presented at the emergency department for long term fatigue and dyspnea that worsened a few days before. Her physical examination r...

Sox9 is a transcription factor of the HMG box DNA binding family involved in chondrocyte differentiation, sexual determination and the development of endoderm-derived-organs. Preliminary results from our laboratory have shown that Sox9 is expressed in the thyroid gland and its regulation is under the control of TSH and TGFβ. In this work we studied the role of Sox9 in the thyroid cells differentiation and its relationship with the other thyroid transcription factors, main...

Objectives: To evaluate the prevalence of hypertension in patients with type 2 diabetes mellitus (T2DM) and to analyze the clinical characteristics, the degree of achieved control and the associated antihypertensive treatment.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, associated antihypertensive treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was co...

Objectives: To evaluate the prevalence of cardiovascular disease (CVD) and associated risk factors in patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about several cardiovascular risk factors was collected (age, sex, smoking, hypertension and dyslipidemia). Also, data about coronary heart disease (CHD) and...

Objectives: To evaluate the characteristics of patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting and to analyze associated antidiabetic treatment and metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about age, sex, body mass index (BMI), associated antidiabetic treatment, and HbA1c was collected.Results: Seventy nin...

Objectives: To evaluate the use of antidepressant drugs in patients with type 2 diabetes mellitus (T2DM) and to analyse if these drugs are associated with a more deteriorated metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, T2DM evolution, body mass index (BMI), HbA1c and associated antidepressant treatment was collected. Statistical analysis was performed with SPS...